pregnant on semaglutide Surprise 'Ozempic babies' underscore links between obesity and fertility | Your Pregnancy Matters Is Ozempic safe to take

The pivotal Phase 2 trial a 48-week study published in The New England Journal of Medicine in 2023 produced these results in adults with obesity (and no diabetes), at the highest dose of 12 mg weekly: Average weight loss of around 24% from baseline A clear dose-response, with even the 4 mg dose producing roughly 17% weight loss Continued weight loss right up to the 48-week endpoint, with no plateau in sight For context, similar Phase 2 data for Wegovy showed around 15% weight loss at 68 weeks

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Semaglutide is most often determined using liquid chromatography coupled with tandem mass spectrometry